Literature summary for 3.2.1.18 extracted from

Hurt, A.C.; Holien, J.K.; Parker, M.; Kelso, A.; Barr, I.G.
Zanamivir-resistant influenza viruses with a novel neuraminidase mutation (2009), J. Virol., 83, 10366-10373.

Search for more literature for 3.2.1.18

Protein Variants

Protein Variants	Comment	Organism
Q136K	the neuraminidase mutation has no effect on oseltamivir susceptibility but causes approximately a 300fold and a 70fold reduction in zanamivir and peramivir susceptibility, respectively. The mutant strain displays greater viral fitness than the wild-type virus in MDCK cells but equivalent infectivity and transmissibility in a ferret model	influenza A virus

Inhibitors

Inhibitors	Comment	Organism	Structure
oseltamivir	-	influenza A virus
peramivir	-	influenza A virus
zanamivir	-	influenza A virus

Organism

Organism	UniProt	Comment	Textmining
influenza A virus	Q07599	H1N1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O	-	influenza A virus	4-methylumbelliferone + N-acetylneuraminic acid	-	?

Synonyms

Synonyms	Comment	Organism
neuraminidase	-	influenza A virus

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Release 2023.1 (January 2023)