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Literature summary for 3.2.1.18 extracted from

  • Parker, D.; Soong, G.; Planet, P.; Brower, J.; Ratner, A.J.; Prince, A.
    The NanA neuraminidase of Streptococcus pneumoniae is involved in biofilm formation (2009), Infect. Immun., 77, 3722-3730.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.18

Inhibitors

Inhibitors Comment Organism Structure
2,3-dehydro-2-deoxy-N-acetylneuraminic acid
-
 Streptococcus pneumoniae
Cu2+ about 40% residual activity at 1 mM Streptococcus pneumoniae
Fe2+ about 10% residual activity at 1 mM Streptococcus pneumoniae
N-acetylneuraminic acid
-
 Streptococcus pneumoniae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4
-
 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid
-
 Streptococcus pneumoniae

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ about 170% activity at 1 mM Streptococcus pneumoniae
Mg2+ about 150% activity at 1 mM Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O Streptococcus pneumoniae
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
-
 Streptococcus pneumoniae ?
-
 ?
alpha(2-6)-sialyllactose + H2O
-
 Streptococcus pneumoniae sialic acid + lactose
-
 ?

Synonyms

Synonyms Comment Organism
NanA
-
 Streptococcus pneumoniae
neuraminidase
-
 Streptococcus pneumoniae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.2
-
-
 Streptococcus pneumoniae 2,3-dehydro-2-deoxy-N-acetylneuraminic acid
0.6
-
-
 Streptococcus pneumoniae N-acetylneuraminic acid

General Information

General Information Comment Organism
physiological function the NanA neuraminidase of Streptococcus pneumoniae is involved in biofilm formation Streptococcus pneumoniae