Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-deoxy-2,3-dehydro-N-acetylneuraminic acid | - |
Homo sapiens | |
4,5-diacetamido-2-fluorobenzoate | 8% inhibition of isoform NEU4 at 1 mM | Homo sapiens | |
4,5-diacetamido-2-fluorobenzoic acid | 23% inhibition of isoform NEU3 at 1 mM; 37% inhibition of isoform NEU2 at 1 mM | Homo sapiens | |
4-acetamido-5-(2-ethylbutanamido)-2-fluorobenzoic acid | 23% inhibition of isoform NEU2 at 1 mM; less than 5% inhibition of isoform NEU4 at 1 mM | Homo sapiens | |
4-acetamido-5-(2-methylbutanamido)-2-fluorobenzoic acid | 7% inhibition of isoform NEU2 at 1 mM | Homo sapiens | |
4-acetamido-5-(2-naphthamido)-2-fluorobenzoic acid | 10% inhibition of isoform NEU4 at 1 mM; 33% inhibition of isoform NEU2 at 1 mM; 8% inhibition of isoform NEU3 at 1 mM | Homo sapiens | |
4-acetamido-5-(biphenyl-4-ylcarboxamido)-2-fluorobenzoic acid | 10% inhibition of isoform NEU4 at 1 mM; 60% inhibition of isoform NEU2 at 1 mM; 8% inhibition of isoform NEU3 at 1 mM | Homo sapiens | |
4-acetamido-5-benzamido-2-fluorobenzoic acid | 17% inhibition of isoform NEU2 at 1 mM | Homo sapiens | |
4-acetamido-5-cyclohexanecarboxamido-2-fluorobenzoic acid | 17% inhibition of isoform NEU2 at 1 mM; 6% inhibition of isoform NEU4 at 1 mM | Homo sapiens | |
4-acetamido-5-cyclopropanecarboxamido-2-fluorobenzoic acid | 20% inhibition of isoform NEU2 at 1 mM; less than 5% inhibition of isoform NEU4 at 1 mM | Homo sapiens | |
4-acetamido-5-isobutyramido-2-fluorobenzoic acid | 11% inhibition of isoform NEU4 at 1 mM; 15% inhibition of isoform NEU2 at 1 mM | Homo sapiens | |
4-acetamido-5-pentanamido-2-fluorobenzoic acid | 13% inhibition of isoform NEU3 at 1 mM; 25% inhibition of isoform NEU2 at 1 mM; less than 5% inhibition of isoform NEU4 at 1 mM | Homo sapiens | |
4-acetamido-5-pivalamido-2-fluorobenzoic acid | less than 5% inhibition of isoform NEU4 at 1 mM | Homo sapiens | |
additional information | no inhibition by 4-acetamido-5-cyclopentanecarboxamido-2-fluoro benzoic acid of isoform NEU1 at 1 mM; no inhibition by 4-acetamido-5-cyclopentanecarboxamido-2-fluoro benzoic acid of NEU2 isoform at 1 mM; no inhibition by 4-acetamido-5-cyclopentanecarboxamido-2-fluoro benzoic acid of NEU3 isoform at 1 mM; no inhibition by 4-acetamido-5-cyclopentanecarboxamido-2-fluoro benzoic acid of NEU4 isoform at 1 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoform NEU2 | Homo sapiens | 5829 | - |
lysosome | - |
Homo sapiens | 5764 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
plasma membrane | isoform NEU3 | Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8WWR8 | - |
- |
Homo sapiens | Q99519 | - |
- |
Homo sapiens | Q9UQ49 | - |
- |
Homo sapiens | Q9Y3R4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O | - |
Homo sapiens | 4-methylumbelliferone + N-acetylneuraminic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-N-acylneuraminate glycohydrolase | - |
Homo sapiens |
exo-alpha-sialidase | - |
Homo sapiens |
NEU1 | isoform | Homo sapiens |
NEU2 | isoform | Homo sapiens |
Neu3 | isoform | Homo sapiens |
NEU4 | isoform | Homo sapiens |
neuramindase | - |
Homo sapiens |
sialidase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.552 | - |
isoform NEU2 | Homo sapiens | 4-acetamido-5-(biphenyl-4-ylcarboxamido)-2-fluorobenzoic acid | |
5 | - |
IC50 above 5 mM, isoform NEU3 | Homo sapiens | 4-acetamido-5-(biphenyl-4-ylcarboxamido)-2-fluorobenzoic acid | |
5 | - |
IC50 above 5 mM, isoform NEU4 | Homo sapiens | 4-acetamido-5-(biphenyl-4-ylcarboxamido)-2-fluorobenzoic acid |