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Literature summary for 3.2.1.18 extracted from

  • Neres, J.; Brewer, M.L.; Ratier, L.; Botti, H.; Buschiazzo, A.; Edwards, P.N.; Mortenson, P.N.; Charlton, M.H.; Alzari, P.M.; Frasch, A.C.; Bryce, R.A.; Douglas, K.T.
    Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening (2009), Bioorg. Med. Chem. Lett., 19, 589-596.
    View publication on PubMed
Search for more literature for 3.2.1.18

Inhibitors

Inhibitors Comment Organism Structure
(3E)-3-(1,3-benzothiazol-2-yl)-4-(2,5-dimethylphenyl)but-3-enoate
-
 Trypanosoma cruzi
(3E)-3-(1,3-benzothiazol-2-yl)-4-(2-ethoxyphenyl)but-3-enoate
-
 Trypanosoma cruzi
(3E)-3-(1,3-benzothiazol-2-yl)-4-(3,4-dimethoxyphenyl)but-3-enoate
-
 Trypanosoma cruzi
(3E)-3-(1,3-benzothiazol-2-yl)-4-(3-fluorophenyl)but-3-enoate
-
 Trypanosoma cruzi
(3E)-3-(1,3-benzothiazol-2-yl)-4-[2-(propan-2-yloxy)phenyl]but-3-enoate
-
 Trypanosoma cruzi
(3E)-3-(1,3-benzothiazol-2-yl)-4-[2-methyl-5-(trifluoromethyl)phenyl]but-3-enoate
-
 Trypanosoma cruzi
2-([4,5-dimethyl-3-(propoxycarbonyl)thiophen-2-yl]carbamoyl)cyclohexanecarboxylate
-
 Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
-
 Trypanosoma cruzi 4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.12
-
-
 Trypanosoma cruzi (3E)-3-(1,3-benzothiazol-2-yl)-4-(2,5-dimethylphenyl)but-3-enoate
0.12
-
-
 Trypanosoma cruzi (3E)-3-(1,3-benzothiazol-2-yl)-4-(3-fluorophenyl)but-3-enoate
0.15
-
-
 Trypanosoma cruzi (3E)-3-(1,3-benzothiazol-2-yl)-4-[2-(propan-2-yloxy)phenyl]but-3-enoate
0.15
-
-
 Trypanosoma cruzi (3E)-3-(1,3-benzothiazol-2-yl)-4-[2-methyl-5-(trifluoromethyl)phenyl]but-3-enoate
0.16
-
-
 Trypanosoma cruzi (3E)-3-(1,3-benzothiazol-2-yl)-4-(2-ethoxyphenyl)but-3-enoate
0.18
-
-
 Trypanosoma cruzi (3E)-3-(1,3-benzothiazol-2-yl)-4-(3,4-dimethoxyphenyl)but-3-enoate
0.21
-
-
 Trypanosoma cruzi 2-([4,5-dimethyl-3-(propoxycarbonyl)thiophen-2-yl]carbamoyl)cyclohexanecarboxylate