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Literature summary for 3.2.1.18 extracted from

  • Burnaugh, A.M.; Frantz, L.J.; King, S.J.
    Growth of Streptococcus pneumoniae on human glycoconjugates is dependent upon the sequential activity of bacterial exoglycosidases (2008), J. Bacteriol., 190, 221-230.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.18

Protein Variants

Protein Variants Comment Organism
additional information in neuraminidase NanA deletion mutant, NanB can partially support the growth of pneumococci on glycoconjugates Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus pneumoniae NanB may contribute to Strreptococcus pneumoniae colonization and pathogenesis ?
-
 ?
additional information Streptococcus pneumoniae Streptococcus pneumoniae is able to utilize complex N-linked human glycoconjugates as a sole source of carbon to sustain growth and efficient growth is dependent upon the sequential deglycosylation of the glycoconjugate substrate by pneumococcal exoglycosidases NanA, BgaA, and StrH. The second pneumococcal neuraminidase, NanB, is involved in the deglycosylation of host glycoconjugates and NanB activity can partially compensate for the loss or dysfunction of NanA ?
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 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
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-
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Streptococcus pneumoniae Q54727
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NanB may contribute to Strreptococcus pneumoniae colonization and pathogenesis Streptococcus pneumoniae ?
-
 ?
additional information Streptococcus pneumoniae is able to utilize complex N-linked human glycoconjugates as a sole source of carbon to sustain growth and efficient growth is dependent upon the sequential deglycosylation of the glycoconjugate substrate by pneumococcal exoglycosidases NanA, BgaA, and StrH. The second pneumococcal neuraminidase, NanB, is involved in the deglycosylation of host glycoconjugates and NanB activity can partially compensate for the loss or dysfunction of NanA Streptococcus pneumoniae ?
-
 ?

Synonyms

Synonyms Comment Organism
NanB
-
 Streptococcus pneumoniae