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Literature summary for 3.2.1.18 extracted from
- Isolation and characterization of a sialidase from the starfish Asterias rubens (1989), Biol. Chem. Hoppe-Seyler, 370, 183-190.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Deoxy-2,3-didehydro-N-acetylneuraminic acid | - |
Asterias rubens |  |
| 2-Deoxy-2,3-didehydro-N-acetylneuraminic acid | - |
Homo sapiens | |
| Cu2+ | - |
Asterias rubens | |
| Cu2+ | - |
Homo sapiens | |
| Hg2+ | - |
Asterias rubens | |
| Hg2+ | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
| lysosome | - |
Asterias rubens | 5764 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 63000 | - |
4 * 63000, SDS-PAGE | Asterias rubens |
| 230000 | - |
gel filtration | Asterias rubens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Asterias rubens | - |
starfish | - |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Asterias rubens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0005 | - |
leukocytes | Homo sapiens |
| 0.0014 | - |
- |
Asterias rubens |
| 0.0024 | - |
liver | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O | - |
Homo sapiens | 4-methylumbelliferone + N-acetylneuraminic acid | - |
? | |
| 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O | - |
Asterias rubens | 4-methylumbelliferone + N-acetylneuraminic acid | - |
? | |
| fetuin + H2O | - |
Homo sapiens | ? | - |
? | |
| fetuin + H2O | - |
Asterias rubens | ? | - |
? | |
| sialyl-alpha-2,3-lactose + H2O | - |
Homo sapiens | ? | - |
? | |
| sialyl-alpha-2,3-lactose + H2O | - |
Asterias rubens | ? | - |
? | |
| sialyl-alpha-2,6-lactose + H2O | - |
Homo sapiens | ? | - |
? | |
| sialyl-alpha-2,6-lactose + H2O | - |
Asterias rubens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 63000, SDS-PAGE | Asterias rubens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Asterias rubens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.2 | - |
- |
Asterias rubens |
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