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Literature summary for 3.2.1.17 extracted from

  • Huang, P.; Li, W.S.; Xie, J.; Yang, X.M.; Jiang, D.K.; Jiang, S.; Yu, L.
    Characterization and expression of HLysG2, a basic goose-type lysozyme from the human eye and testis (2011), Mol. Immunol., 48, 524-531.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of the mature peptide-coding region in Pichia pastoris strain GS115 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Na+ activates, best at 75 mM Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21508
-
x * 21508, sequence calculation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86SG7
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme from Pichia pastoris strain GS115 by chitin affinity chromatography and gel filtration to homogeneity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
eye weak enzyme expression in the conjuctival sample, strong expression in the lacrimal gland sample Homo sapiens
-
tear
-
Homo sapiens
-
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a suspension of Micrococcus lysodeikticus is used as a substrate for HLysG2 Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 21508, sequence calculation Homo sapiens

Synonyms

Synonyms Comment Organism
g-type lysozyme
-
Homo sapiens
Goose-type lysozyme
-
Homo sapiens
HLysG2
-
Homo sapiens
lysozyme g-like 2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
recombinant enzyme Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
recombinant enzyme Homo sapiens

General Information

General Information Comment Organism
physiological function lysozyme plays an important role in human innate immunity by causing bacterial cell lysis. Recombinant HlysG2 inhibits Gram-positive bacterial growth, but does not inhibit Gram-negative bacterial and Candida albicans growth. HLysG2 is a potent antibacterial protein that may play a role in the innate immunity of the human eye Homo sapiens