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Literature summary for 3.2.1.17 extracted from

  • Krupyanskii, Y.; Knox, P.; Loiko, N.; Abdulnasirov, E.; Korotina, O.; Stepanov, S.; Zakharova, N.; Nikolaev, Y.; El-Registan, G.; Rubin, A.
    Influence of chemical chaperones on the properties of lysozyme and the reaction center protein from Rhodobacter sphaeroides (2011), Biofizika, 56, 8-23.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
4-hexylresorcinol activates at low concentrations, up to 10-15 molcules of hexylresorcinol per protein globule, but inhibits at higher concentrations, at above 100 molecules of hexylresorcinol per protein globule the activity is abolished Gallus gallus
5-methylresorcinol interacts with the surface of lysozyme directly, not via water hydrogen bonds. This leads to a decrease in the denaturation temperature and an increase in the amplitude of equilibrium fluctuations, allowing it to be a powerful activator Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
4-hexylresorcinol activates at low concentrations, up to 10-15 molcules of hexylresorcinol per protein globule, but inhibits at higher concentrations, at above 100 molecules of hexylresorcinol per protein globule the activity is abolished Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Gallus gallus
-
-

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Gallus gallus
-
egg white
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Micrococcus luteus cells in the exponential growth phase are used as substrate Gallus gallus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37 42 assay at Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 7 assay at Gallus gallus

General Information

General Information Comment Organism
physiological function influence of the chemical chaperones 4-hexylresorcinol, and 5-methylresorcinol on the structure, equilibrium fluctuations, and functional activity of the hydrophilic enzyme lysozyme, molecular dynamics, overview Gallus gallus