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Literature summary for 3.2.1.108 extracted from
- A comparative study on the metabolism of Epimedium koreanum nakai-prenylated flavonoids in rats by an intestinal enzyme (lactase phlorizin hydrolase) and intestinal flora (2014), Molecules, 19, 177-203.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| gluconolactone | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| baohuoside I + H2O | Rattus norvegicus | from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract | ? + D-glucose | - |
? | |
| epimedin A + H2O | Rattus norvegicus | from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract | ? + D-glucose | - |
? | |
| epimedin B + H2O | Rattus norvegicus | from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract | ? + D-glucose | - |
? | |
| epimedin C + H2O | Rattus norvegicus | from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract | ? + D-glucose | - |
? | |
| icariin + H2O | Rattus norvegicus | from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract | ? + D-glucose | - |
? | |
| additional information | Rattus norvegicus | the enzyme has two distinct catalytic active sites, one for the hydrolysis of lactose and flavonoid glucosides and another, phlorizin hydrolase, for the hydrolysis of phlorizin and glucosylceramides | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Rattus norvegicus | - |
| small intestine | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| baohuoside I + H2O | - |
Rattus norvegicus | ? + D-glucose | - |
? | |
| baohuoside I + H2O | from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract | Rattus norvegicus | ? + D-glucose | - |
? | |
| epimedin A + H2O | - |
Rattus norvegicus | ? + D-glucose | - |
? | |
| epimedin A + H2O | from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract | Rattus norvegicus | ? + D-glucose | - |
? | |
| epimedin B + H2O | - |
Rattus norvegicus | ? + D-glucose | - |
? | |
| epimedin B + H2O | from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract | Rattus norvegicus | ? + D-glucose | - |
? | |
| epimedin C + H2O | - |
Rattus norvegicus | ? + D-glucose | - |
? | |
| epimedin C + H2O | from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract | Rattus norvegicus | ? + D-glucose | - |
? | |
| icariin + H2O | - |
Rattus norvegicus | ? + D-glucose | - |
? | |
| icariin + H2O | from Yinyanghuo (Herba Epimdii, YYH) is a popular Traditional Chinese Medicine tonic for kidney-reinforcing from Epimedium koreanum Nakai herb extract | Rattus norvegicus | ? + D-glucose | - |
? | |
| additional information | the enzyme has two distinct catalytic active sites, one for the hydrolysis of lactose and flavonoid glucosides and another, phlorizin hydrolase, for the hydrolysis of phlorizin and glucosylceramides | Rattus norvegicus | ? | - |
? | |
| additional information | activity by the isolated intestinal enzyme on flavonoid glucosides in descending order: icariin, epimedin A, epimedin C, epimedin B, amd baohuoside I, mass spectrometric product analysis, detailed overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lactase phlorizin hydrolase | - |
Rattus norvegicus |
| LPH | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | metabolism of ginsenosides in the intestinal flora of rats, mass spectrometric product analysis, detailed overview | Rattus norvegicus |
| metabolism | the enzyme is responsible for the hydrolysis of prenylated flavonoids (icariin, epimedin A, epimdin B, epimedin C, and baohuoside I) of Yinyanghuo (Herba epimdii) | Rattus norvegicus |
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Release 2023.1 (January 2023)
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