Literature summary for 3.2.1.108 extracted from

Lewinsky, R.H.; Jensen, T.G.; M?ller, J.; Stensballe, A.; Olsen, J.; Troelsen, J.T.
T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro (2005), Hum. Mol. Genet., 14, 3945-3953.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
lactose + H2O	Homo sapiens	the nuclear transcription factor Oct-1 binds to the T variant at position -13910 upstream of the lactase gene and enhances transcription of the lactase gene	D-galactose + D-glucose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
small intestine	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
lactose + H2O	the nuclear transcription factor Oct-1 binds to the T variant at position -13910 upstream of the lactase gene and enhances transcription of the lactase gene	Homo sapiens	D-galactose + D-glucose	-	?

Synonyms

Synonyms	Comment	Organism
lactase-phlorizin hydrolase LPH	-	Homo sapiens

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Release 2023.1 (January 2023)