Application | Comment | Organism |
---|---|---|
medicine | treatment of Pompe Disease | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D404N | same mutant as D518N | Homo sapiens |
D518N | same mutant as D404N | Homo sapiens |
additional information | variant oxime-neo-rhGAA, content of mannose-6-phosphat residues increased, higher affinity for the cation-independent mannose 6-phosphate receptor | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | 50% increased Km-Value of the modified enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | chemical conjucation of synthetic oligosaccharides bearing M6P residues, neo-rhGAA | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-alpha-D-glucopyranoside + H2O | 4°C, pH 6.25 | Homo sapiens | 4-methylumbelliferone + alpha-D-glucose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid alpha-glucosidase | - |
Homo sapiens |
glycoengineered acid alpha-glucosidase | - |
Homo sapiens |
oxime-neo-rhGAA | - |
Homo sapiens |
rhGAA | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
4 | - |
for 90 days, higher stability of the modified enzyme | Homo sapiens |
25 | - |
for 14 days, higher stability of the modified enzyme | Homo sapiens |