Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ethyl caffeate | pH 7.0 | Homo sapiens | |
montbretin A | glycosylated acyl-flavonols, originally isolated from an extract of Crocosmia crocosmiiflora, measured in the presence and in the absence of 5 mM dithiothreitol, competitive inhibitor, more effective than montbretin B and C due to its free meta-hydroxyl group of the cinnamic acid moiety | Homo sapiens | |
montbretin B | glycosylated acyl-flavonols, originally isolated from an extract of Crocosmia crocosmiiflora, less effective than montbretin A due to the hydroxy group of montbretin A in the cinnamic acid moiety, respnsible for the tight binding | Homo sapiens | |
montbretin C | glycosylated acyl-flavonols, a methyl ether of the cinnamic acid moiety, originally isolated from an extract of Crocosmia crocosmiiflora, less effective than montbretin A due to the hydroxy group of montbretin A in the cinnamic acid moiety, respnsible for the tight binding | Homo sapiens | |
additional information | no effect by the addtion of 0.1% dimethyl sulfoxide and 0.01% Triton X-100 | Homo sapiens | |
myricetin | pH 7.0 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3.6 | - |
2-chloro-4-nitrophenyl-alpha-D-maltotrioside | commercial substrate, pH 7.0 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-chloro-4-nitrophenyl-alpha-D-maltotrioside + H2O | commercial substrate for a flourescence-based assay, pH 7.0 | Homo sapiens | 2-chloro-4-nitrophenol + alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranose | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000081 | - |
montbretin A | pH 7.0, in presence of 1 mM CaCl2 | Homo sapiens | |
0.0013 | - |
ethyl caffeate | pH 7.0, uncompetitive inhibition | Homo sapiens | |
0.0036 | - |
montbretin B | pH 7.0, in presence of 1 mM CaCl2 | Homo sapiens | |
0.0061 | - |
montbretin C | pH 7.0, in presence of 1 mM CaCl2 | Homo sapiens | |
0.11 | - |
myricetin | pH 7.0, competitive inhibition | Homo sapiens |