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Literature summary for 3.1.6.8 extracted from

  • Lukatela, G.; Krauss, N.; Theis, K.; Selmer, T.; Gieselmann, V.; von Figura, K.; Saenger, W.
    Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis (1998), Biochemistry, 37, 3654-3664.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
saposin B small activator protein to solubilize hydrophobic substrates Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in BHK cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
aldehyde function and metal ion at the active site Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
enzyme is synthesized as a preprotein with 507 amino acids, the mature protein has 489 amino acids with a calculated mass of 52000 Homo sapiens
50000
-
octamer at acidic pH, dimer at neutral pH Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cerebroside 3-sulfate + H2O Homo sapiens
-
cerebroside + sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15289
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein high-mannose-type oligosaccharide chains Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
of the recombinant protein Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cerebroside 3-sulfate + H2O
-
Homo sapiens cerebroside + sulfate
-
?

Subunits

Subunits Comment Organism
octamer tetramer of dimers Homo sapiens