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Literature summary for 3.1.6.8 extracted from
- Arylsulfatases A and B from human liver (1978), Methods Enzymol., 50, 537-547.
General Stability
| General Stability | Organism |
|---|---|
| bovine serum albumin stabilizes | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CN- | - |
Homo sapiens |  |
| PO43- | - |
Homo sapiens | |
| SO32- | - |
Homo sapiens | |
| SO42- | - |
Homo sapiens | |
| thiol reagents | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 49000 | - |
1 * 49000, 1 * 55000, SDS-PAGE | Homo sapiens |
| 49000 | - |
aggregation to tetramer at higher concentrations around pH 5, 2 * 49000, 2 * 55000 | Homo sapiens |
| 55000 | - |
1 * 49000, 1 * 55000, SDS-PAGE | Homo sapiens |
| 55000 | - |
aggregation to tetramer at higher concentrations around pH 5, 2 * 49000, 2 * 55000 | Homo sapiens |
| 105000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cerebroside 3-sulfate + H2O | Homo sapiens | - |
cerebroside + sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | 5-10% carbohydrate content | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| a cerebroside 3-sulfate + H2O = a cerebroside + sulfate | hydrolyses galactose-3-sulfate residues in a number of lipids, also hydrolyses ascorbate 2-sulfate and many phenol sulfates, enzymes catalyze in addition to reaction of EC 3.1.6.8 also arylsulfatase reaction EC 3.1.6.1 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, protein: 1 mg/ml | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ascorbate 2-sulfate + H2O | - |
Homo sapiens | ascorbate + sulfate | - |
? | |
| cerebroside 3-sulfate + H2O | - |
Homo sapiens | cerebroside + sulfate | - |
? | |
| methylumbelliferyl sulfate + H2O | - |
Homo sapiens | methylumbelliferone + sulfate | - |
? | |
| nitrocatechol sulfate + H2O | - |
Homo sapiens | nitrocatechol + sulfate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 49000, 1 * 55000, SDS-PAGE | Homo sapiens |
| tetramer | aggregation to tetramer at higher concentrations around pH 5, 2 * 49000, 2 * 55000 | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
t1/2: 7 min | Homo sapiens |
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Release 2023.1 (January 2023)
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