Inhibitors | Comment | Organism | Structure |
---|---|---|---|
irosustat | i.e. BN83495 | Homo sapiens | |
additional information | inhibitor development of the enzyme in cancer treatment, clinical studies, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | Homo sapiens | dehydroepiandrosterone is reduced to a diol by 17beta-HSD1, apart from estrone, the steroid sulfatase pathway is also responsible for the production of another steroid with estrogenic properties, namely androstenediol | dehydroepiandrosterone + sulfate | - |
? | |
estrone sulfate + H2O | Homo sapiens | - |
estrone + sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast carcinoma cell | - |
Homo sapiens | - |
additional information | enzyme activity is reduced in menopausal women | Homo sapiens | - |
uterine endometrial carcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | - |
Homo sapiens | dehydroepiandrosterone + sulfate | - |
? | |
dehydroepiandrosterone sulfate + H2O | dehydroepiandrosterone is reduced to a diol by 17beta-HSD1, apart from estrone, the steroid sulfatase pathway is also responsible for the production of another steroid with estrogenic properties, namely androstenediol | Homo sapiens | dehydroepiandrosterone + sulfate | - |
? | |
estrone sulfate + H2O | - |
Homo sapiens | estrone + sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
steroid sulfatase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | relevance and interplay between aromatase, steroid sulfatase, organic anion transporting polypeptide B, and 17beta-hydroxysteroid dehydrogenase type 1 to facilitate local synthesis of estrogenic steroids within breast and other tissues, pathways of local synthesis of estrogenic steroids in neoplastic breast tissue, overview | Homo sapiens |