Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | STS inhibitors were developed to treat breast cancer but could also used to treat endometriosis, polycystic ovarian disease, prostate cancer, and some androgen-dependent skin conditions, such as acne and hirsutism | Mus musculus | |
STX289 | N,N-dimethyl 667 COUMATE, analogue of STX64, inhibition 24 h after oral application: 0.1 mg/kg inhibits liver STS by 45%, skin STS by about 39%, 1 and 10 mg/kg inhibit liver STS completely, skin STS almost completely, inhibition 24 h after topical application to neck skin: 0.1 mg/kg inhibits skin and liver STS by <50%, remote skin STS by about 10%, 1and 10 mg/kg inhibit skin STS by 98%, remote skin STS by about 80 and more than 90% respectively, and liver STS by more than 80 and close by 100% respectively | Mus musculus | |
STX64 | synonym BN83495, inhibition 24 h after oral application: 0.1 mg/kg body mass inhibits liver STS by 79%, skin STS by about 59%, 1 and 10 mg/kg inhibitis liver STS activity completely, skin STS almost completely, inhibition 24 h after topical application to neck skin: 0.1 mg/kg inhibits skin STS by 95%, remote skin STS by about 33%, liver STS by 45%, 1 and 10 mg/kg inhibits skin STS by 99%, remote skin STS almost completely, and liver STS by about 90% | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | Mus musculus | - |
dehydroepiandrosterone + sulfate | subsequent conversion to testosterone or aromatisation to estrone | ? | |
estrone sulfate + H2O | Mus musculus | - |
estrone + sulfate | subsequent conversion to estradiol | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
athymic female MF-1 nude mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
skin | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | - |
Mus musculus | dehydroepiandrosterone + sulfate | subsequent conversion to testosterone or aromatisation to estrone | ? | |
estrone sulfate + H2O | - |
Mus musculus | estrone + sulfate | subsequent conversion to estradiol | ? |
Synonyms | Comment | Organism |
---|---|---|
steroid sulfatase | - |
Mus musculus |
STS | - |
Mus musculus |