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Literature summary for 3.1.6.2 extracted from
- Interactions of the human cytosolic sulfotransferases and steroid sulfatase in the metabolism of tibolone and raloxifene (2007), J. Steroid Biochem. Mol. Biol., 107, 202-210.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | benzothiophene sulfates of raloxifene and arzoxifene used as hormone replacement therapeutic agents are hydrolyzed by the enzyme, whereas the raloxifene 4'-phenolic sulfate is resistant. Tissue specific expression of sulfotransferase isoforms and of steroid sulfatase can be important in the inactivation and regeneration of the active form of hormone replacement therapeutic agents | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arzoxifene sulfate + H2O | product of sulfotransferase reaction on arzoxifene used in hormone replacement therapy | Homo sapiens | arzoxifene + sulfate | - |
? |  |
| additional information | no substrate: tibolone 17-sulfate | Homo sapiens | ? | - |
? | |
| raloxifene sulfate + H2O | product of sulfotransferase reaction on raloxifene used in hormone replacement therapy, the benzothiophene sulfate is substrate, the 4'-phenolic sulfate is no substrate for enzyme | Homo sapiens | raloxifene + sulfate | - |
? | |
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