Literature summary for 3.1.6.2 extracted from

Sugawara, T.; Nomura, E.; Hoshi, N.
Both N-terminal and C-terminal regions of steroid sulfatase are important for enzyme activity (2006), J. Endocrinol., 188, 365-374.

Search for more literature for 3.1.6.2

Application

Application	Comment	Organism
medicine	study on the effect of N-and C-terminal trucated enzyme mimicking enzyme deficiency in X-linked ichthyosis	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	c-terminal truncation mutant using codons 1-559, no effects on protein synthesis and degradation, dominant negative effect on enzyme activity when coexisting with wild-type enzyme	Homo sapiens
Q560P	no effect of mutation on enzyme synthesis and degradation, dominant negative effect on enzyme activity when coexisting with wild-type enzyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	expression in COS-1 cell	-

Subunits

Subunits	Comment	Organism
dimer	coprecipitation of mutant enzyme with FLAG-tagged enzyme	Homo sapiens

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Release 2023.1 (January 2023)