Literature summary for 3.1.6.2 extracted from

Hughes, P.J.; Steinmeyer, A.; Chandraratna, R.A.; Brown, G.
1alpha,25-dihydroxyvitamin D3 stimulates steroid sulphatase activity in HL60 by and NB4 acute myeloid leukaemia cell lines different receptor-mediated mechanisms (2005), J. Cell. Biochem., 94, 1175-1189.

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Activating Compound

Activating Compound	Comment	Organism	Structure
1alpha,25-dihydroxyvitamin D3	upregulation of enzyme activity. In HL-60 cell, stimulation is augmented by retinoid X-receptor agonists, blocked by retinoid X-receptor specific antagonists, and retinoic acid receptor specific agonists and antagonist have no effect. In NB-4 cell, upregulation is unaffected by the specific classical nuclear vitamin D receptor and retinoid X-receptor antagonists, but is blocked by a plasma-membrane associated vitamin D receptor antagonist and increases by plasma-membrane associated vitamin D receptor agonists	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	acute myeloid leukaemia cell line	Homo sapiens	-
NB-4 cell	acute myeloid leukaemia cell line	Homo sapiens	-

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Release 2023.1 (January 2023)