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Literature summary for 3.1.6.2 extracted from

  • Tobacman, J.K.; Hinkhouse, M.; Khalkhali-Ellis, Z.
    Steroid sulfatase activity and expression in mammary myoepithelial cells (2002), J. Steroid Biochem. Mol. Biol., 81, 65-68.
    View publication on PubMed
Search for more literature for 3.1.6.2

Activating Compound

Activating Compound Comment Organism Structure
17beta estradiol exposure to 17beta estradiol causes 9% increase of estrone 3-sulfate sulfatase activity in mammary myoepithelial cells after 6 days, but 70% reduction in MCF-7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
17beta estradiol exposure to 17beta estradiol causes 70% reduction of estrone 3-sulfate sulfatase activity in MCF-7 cells after 6 days, but 9% increase in mammary myoepithelial cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0036
-
 dehydroepiandrosterone sulfate 37°C, MCF-7 cells Homo sapiens
0.0063
-
 Estrone 3-sulfate 37°C, MCF-7 cells Homo sapiens
0.013
-
 dehydroepiandrosterone sulfate 37°C, mammary myoepithelial cells Homo sapiens
0.035
-
 Estrone 3-sulfate 37°C, mammary myoepithelial cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone sulfate + H2O Homo sapiens hydrolyzes dehydroepiandrosterone sulfate to its active, unsulfated form dehydroepiandrosterone + sulfate
-
 ?
estrone 3-sulfate + H2O Homo sapiens hydrolyzes estrone 3-sulfate to its active, unsulfated form estrone + sulfate
-
 ?
additional information Homo sapiens in vivo the activity of STS in the mammary myoepithelial cells may influence the availability of active, unsulfated hormones to the adjacent epithelial cells within mammary tissue and may have a role in the regulation of mammary growth and development ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mammary myoepithelial cell from normal mammary tissue, slightly lower STS mRNA expression but 120times higher STS activity than in MCF-7 cells Homo sapiens
-
MCF-7 cell derived from a metastatic malignant mammary epithelial cell line, slightly higher STS mRNA expression but 120times lower STS activity than in mammary myoepithelial cells Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone sulfate + H2O
-
 Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
dehydroepiandrosterone sulfate + H2O hydrolyzes dehydroepiandrosterone sulfate to its active, unsulfated form Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
estrone 3-sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
estrone 3-sulfate + H2O hydrolyzes estrone 3-sulfate to its active, unsulfated form Homo sapiens estrone + sulfate
-
 ?
additional information in vivo the activity of STS in the mammary myoepithelial cells may influence the availability of active, unsulfated hormones to the adjacent epithelial cells within mammary tissue and may have a role in the regulation of mammary growth and development Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
STS
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens