Application | Comment | Organism |
---|---|---|
pharmacology | steroid sulfatase inhibitors could be novel drugs to treat androgen-dependent disorders of the hair follicle such as androgenetic alopecia or hirsutism | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
estrone-3-O-sulfamate | specific inhibitor, concentration-dependent, complete inhibition at 0.1 mM, 100 nM and 10 nM, 89% inhibition at 1 nM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0017 | - |
dehydroepiandrosterone sulfate | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | Homo sapiens | androgen metabolism, dehydroepiandrosterone sulfate may play a part in the pathogenesis of androgenic alopecia | dehydroepiandrosterone + sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hair follicle | scalp biopsies, beard and occipital hair follicles ex vivo, predominantly expressed in the dermal papilla | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
higher specific activity in the dermal papilla by a factor of 6-8 than in the connective tissue sheaths or root sheaths | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | - |
Homo sapiens | dehydroepiandrosterone + sulfate | - |
? | |
dehydroepiandrosterone sulfate + H2O | androgen metabolism, dehydroepiandrosterone sulfate may play a part in the pathogenesis of androgenic alopecia | Homo sapiens | dehydroepiandrosterone + sulfate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |