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Literature summary for 3.1.6.2 extracted from
- Gonadal steroid sulfates and sulfatase. V. Human testicular steroid sulfatase: partial characterization and possible regulation by free steroids (1972), Biochim. Biophys. Acta, 258, 473-483.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-pregnen-3beta,21-diol | most potent inhibitor of C21 steroids | Homo sapiens |  |
| 5-pregnen-3beta,21-diol-20-one | most potent inhibitor of C21 steroids | Homo sapiens | |
| 5alpha-androstane-3alpha-17beta-diol | most potent inhibitor of C19 steroids | Homo sapiens | |
| Steroids | overview, e.g. estrone, estradiol, C21 steroids, C19 steroids | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00073 | - |
pregnenolone 3-sulfate | - |
Homo sapiens | |
| 0.00313 | - |
androstenediol 3-sulfate | - |
Homo sapiens | |
| 0.00385 | - |
dehydroepiandrosterone 3-sulfate | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| steroid sulfates + H2O | Homo sapiens | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| androstenediol 3-sulfate + H2O | - |
Homo sapiens | androstenediol + sulfate | - |
? | |
| androstenediol-3-sulfate + H2O | - |
Homo sapiens | androstenediol + sulfate | - |
? | |
| dehydroepiandrosterone 3-sulfate + H2O | - |
Homo sapiens | dehydroepiandrosterone + sulfate | - |
? | |
| pregnenolone sulfate + H2O | - |
Homo sapiens | pregnenolone + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Homo sapiens | steroid + sulfate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.2 | - |
Homo sapiens |
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