Any feedback?
Literature summary for 3.1.6.2 extracted from
- Arylsulfatase C and the streroid sulfatases (1985), Isozymes Curr. Top. Biol. Med. Res., 12, 189-228.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | also associated with multiple sulfatase deficiency | Homo sapiens |
| medicine | deficiency in X-linked placental insufficiency and X-linked ichthyosis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CN- | - |
Aspergillus nidulans |  |
| CN- | - |
Chlamydomonas reinhardtii | |
| CN- | - |
Homo sapiens | |
| CN- | - |
Mus musculus | |
| CN- | - |
Pseudomonas aeruginosa | |
| CN- | - |
Rattus norvegicus | |
| Na-tetraborate | - |
Mus musculus | |
| Na-tetraborate | - |
Rattus norvegicus | |
| Na2B4O7 | - |
Aspergillus nidulans | |
| Na2B4O7 | - |
Chlamydomonas reinhardtii | |
| Na2B4O7 | - |
Homo sapiens | |
| Na2B4O7 | - |
Mus musculus | |
| Na2B4O7 | - |
Pseudomonas aeruginosa | |
| Na2B4O7 | - |
Rattus norvegicus | |
| p-Nitrophenyl sulfate | - |
Aspergillus nidulans | |
| p-Nitrophenyl sulfate | - |
Bos taurus | |
| p-Nitrophenyl sulfate | - |
Chlamydomonas reinhardtii | |
| p-Nitrophenyl sulfate | - |
Homo sapiens | |
| p-Nitrophenyl sulfate | - |
Mus musculus | |
| p-Nitrophenyl sulfate | - |
Pseudomonas aeruginosa | |
| p-Nitrophenyl sulfate | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.007 | - |
p-Nitrophenyl sulfate | - |
Chlamydomonas reinhardtii | |
| 0.45 | - |
methylumbelliferyl sulfate | hydropobic form | Mus musculus | |
| 1.32 | - |
p-Nitrophenyl sulfate | - |
Homo sapiens | |
| 1.8 | - |
p-Nitrophenyl sulfate | - |
Rattus norvegicus | |
| 2.5 | - |
methylumbelliferyl sulfate | hydrophilic form | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | integral membrane protein | Mus musculus | 16020 | - |
| membrane | integral membrane protein | Homo sapiens | 16020 | - |
| membrane | integral membrane protein | Rattus norvegicus | 16020 | - |
| microsome | - |
Chlamydomonas reinhardtii | - |
- |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Bos taurus | - |
- |
| microsome | - |
Aspergillus nidulans | - |
- |
| microsome | - |
Pseudomonas aeruginosa | - |
- |
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| nucleus | - |
Mus musculus | 5634 | - |
| nucleus | - |
Rattus norvegicus | 5634 | - |
| soluble | - |
Chlamydomonas reinhardtii | - |
- |
| soluble | - |
Aspergillus nidulans | - |
- |
| soluble | - |
Pseudomonas aeruginosa | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22900 | 174000 | series of isoenzymes | Rattus norvegicus |
| 44000 | - |
- |
Aspergillus nidulans |
| 60000 | - |
- |
Mus musculus |
| 60000 | - |
- |
Pseudomonas aeruginosa |
| 74000 | - |
6 * 74000, placenta, SDS-PAGE | Rattus norvegicus |
| 103000 | 105000 | brain | Homo sapiens |
| 150000 | - |
- |
Chlamydomonas reinhardtii |
| 280000 | - |
gel filtration | Rattus norvegicus |
| 440000 | - |
placenta | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| steroid sulfates + H2O | Chlamydomonas reinhardtii | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | Mus musculus | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | Homo sapiens | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | Rattus norvegicus | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | Bos taurus | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | Aspergillus nidulans | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | Pseudomonas aeruginosa | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus nidulans | - |
- |
- |
| Bos taurus | - |
- |
- |
| Chlamydomonas reinhardtii | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Pseudomonas aeruginosa | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | high mannose-type | Homo sapiens |
| glycoprotein | high mannose-type | Rattus norvegicus |
| glycoprotein | contains sialic acid | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| placenta | - |
Homo sapiens | - |
| skin | cultured fibroblasts | Homo sapiens | - |
| spleen | - |
Mus musculus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O | - |
Chlamydomonas reinhardtii | 3beta-hydroxyandrost-5-en-17-one + sulfate | - |
? | |
| 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O | - |
Mus musculus | 3beta-hydroxyandrost-5-en-17-one + sulfate | - |
? | |
| 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O | - |
Homo sapiens | 3beta-hydroxyandrost-5-en-17-one + sulfate | - |
? | |
| 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O | - |
Rattus norvegicus | 3beta-hydroxyandrost-5-en-17-one + sulfate | - |
? | |
| 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O | - |
Aspergillus nidulans | 3beta-hydroxyandrost-5-en-17-one + sulfate | - |
? | |
| 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O | - |
Pseudomonas aeruginosa | 3beta-hydroxyandrost-5-en-17-one + sulfate | - |
? | |
| methylumbelliferyl sulfate + H2O | - |
Mus musculus | methylumbelliferone + sulfate | - |
? | |
| p-nitrophenyl-sulfate + H2O | - |
Bos taurus | p-nitrophenol + sulfate | - |
? | |
| p-nitrophenyl-sulfate + H2O | arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein | Chlamydomonas reinhardtii | p-nitrophenol + sulfate | - |
? | |
| p-nitrophenyl-sulfate + H2O | arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein | Mus musculus | p-nitrophenol + sulfate | - |
? | |
| p-nitrophenyl-sulfate + H2O | arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein | Homo sapiens | p-nitrophenol + sulfate | - |
? | |
| p-nitrophenyl-sulfate + H2O | arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein | Rattus norvegicus | p-nitrophenol + sulfate | - |
? | |
| p-nitrophenyl-sulfate + H2O | arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein | Aspergillus nidulans | p-nitrophenol + sulfate | - |
? | |
| p-nitrophenyl-sulfate + H2O | arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein | Pseudomonas aeruginosa | p-nitrophenol + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Chlamydomonas reinhardtii | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Mus musculus | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Homo sapiens | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Rattus norvegicus | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Bos taurus | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Aspergillus nidulans | steroid + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Pseudomonas aeruginosa | steroid + sulfate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | - |
Homo sapiens |
| hexamer | 6 * 74000, placenta, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein | Chlamydomonas reinhardtii |
| More | arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein | Mus musculus |
| More | arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein | Homo sapiens |
| More | arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein | Rattus norvegicus |
| More | arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein | Aspergillus nidulans |
| More | arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein | Pseudomonas aeruginosa |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
t1/2: 11 min | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.7 | - |
Aspergillus nidulans |
| 6.8 | - |
- |
Homo sapiens |
| 7.5 | 8 | placenta | Homo sapiens |
| 8 | - |
- |
Homo sapiens |
| 8 | - |
esterone 3-sulfate | Rattus norvegicus |
| 9 | - |
- |
Pseudomonas aeruginosa |
| 9 | 9.8 | - |
Chlamydomonas reinhardtii |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
