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Literature summary for 3.1.6.13 extracted from

  • Coronado-Pons, I.; Novials, A.; Casas, S.; Clark, A.; Gomis, R.
    Identification of iduronate-2-sulfatase (IDS) in mouse pancreatic islets (2004), Am. J. Physiol., 10, 1-33.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information When islets are cultured in different concentrations of D-glucose, the levels of enzyme mRNA increases, in a dose-dependent manner. Mannoheptulose completely blocks the effect of glucose. Mus musculus

Application

Application Comment Organism
medicine in humans, the inherited deficiency of the enzyme activity results in mucopolysaccharidosis type II, the Hunter syndrome Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in islets, alpha and beta clonal cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information in 25 Hunter syndrome patients 20 mutations of the gene are identified of which 13 mutations are novel Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Mus musculus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus The enzyme has a potential role in normal pathway of lysosomal degradation of secretory peptides and is likely to be essential to maintain pancreatic beta-cell function ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic islet
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information The enzyme has a potential role in normal pathway of lysosomal degradation of secretory peptides and is likely to be essential to maintain pancreatic beta-cell function Mus musculus ?
-
?