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Literature summary for 3.1.6.13 extracted from

  • Millat, G.; Froissart, R.; Maire, I.; Bozon, D.
    Characterization of iduronate sulphatase mutants affecting N-glycosylation sites and the cysteine-84 residue (1997), Biochem. J., 326, 243-247.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.6.13

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS cells and lymphoblastoid cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C84A loss of activity in mutant Homo sapiens
C84T loss of activity in mutant Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 mature form after deglycosylation, recombinant protein, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dermatan sulfate + H2O Homo sapiens
-
 dermatan + sulfate
-
 ?
heparan sulfate + H2O Homo sapiens
-
 dermatan + sulfate
-
 ?
heparin + H2O Homo sapiens
-
 desulfated heparin + sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein eight glycosylation sites Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dermatan sulfate + H2O
-
 Homo sapiens dermatan + sulfate
-
 ?
heparan sulfate + H2O
-
 Homo sapiens dermatan + sulfate
-
 ?
heparin + H2O
-
 Homo sapiens desulfated heparin + sulfate
-
 ?
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + H2O
-
 Homo sapiens O-(alpha-L-idopyranosyluronic acid)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + sulfate
-
 ?