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Literature summary for 3.1.6.13 extracted from
- Identification and partial characterization of two enzyme forms of iduronate sulfatase from human placenta (1981), Biochim. Biophys. Acta, 661, 106-111.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | - |
Homo sapiens |  |
| phosphate | - |
Homo sapiens | |
| SO42- | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.013 | - |
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate | form A | Homo sapiens | |
| 0.015 | - |
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate | form B | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | 115000 | form A, gel filtration, SDS-PAGE | Homo sapiens |
| 81000 | 83000 | form B, gel filtration | Homo sapiens |
| 83000 | 94000 | form A, sucrose density gradient centrifugation | Homo sapiens |
| 170000 | 190000 | form B, sucrose density gradient centrifugation | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dermatan sulfate + H2O | Homo sapiens | - |
dermatan + sulfate | - |
? | |
| heparan sulfate + H2O | Homo sapiens | - |
dermatan + sulfate | - |
? | |
| heparin + H2O | Homo sapiens | - |
desulfated heparin + sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
2 forms: A, B | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | contains sialic acid residues | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dermatan sulfate + H2O | - |
Homo sapiens | dermatan + sulfate | - |
? | |
| heparan sulfate + H2O | - |
Homo sapiens | dermatan + sulfate | - |
? | |
| heparin + H2O | - |
Homo sapiens | desulfated heparin + sulfate | - |
? | |
| O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + H2O | - |
Homo sapiens | O-(alpha-L-idopyranosyluronic acid)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + sulfate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
stable for 5 min | Homo sapiens |
| 55 | - |
30 min, 50% loss of activity of form A, 45 min, 50% loss of activity of form B | Homo sapiens |
| 64 | - |
5 min, 50% loss of activity | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4 | - |
- |
Homo sapiens |
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