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Literature summary for 3.1.6.1 extracted from

  • Bognar, S.K.; Foretic, B.; Furac, I.; Vukelic, Z.; Grubesic, Z.
    Kinetics and activity of arylsulfatase A in leukocytes derived from patients with cerebral palsy (2006), Acta Pharm., 56, 95-104.
    View publication on PubMed

Application

Application Comment Organism
medicine leukocytes of patients with cerebral palsy show lower enzyme activity as compared to control. Km value for 4-nitrocatechol sulfate in patients' leukocytes is about 0.26 mM, in control 0.21 mM, whereas Vmax value in patients reaches only 58% of healthy control. All investigated patients reveal presence of the most common mutations associated with enzyme pseudodeficiency Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.21
-
4-nitrocatechol sulfate pH 5.0, 37°C, wild-type Homo sapiens
0.26
-
4-nitrocatechol sulfate pH 5.0, 37°C, patient with cerebral palsy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
patients with cerebral palsy
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrocatechol sulfate + H2O
-
Homo sapiens 4-nitrocatechol + sulfate
-
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