Cloned (Comment) | Organism |
---|---|
expression of PDE4B4 cDNA in COS7 cells. Treatment of COS7 cells with forskolin, to elevate cAMP levels, produced activation of PDE4B4, which is associated with the phosphorylation of PDE4B4 on Ser56 within UCR1 | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rolipram | i.e. 4-[3-(cyclopentoxyl)-4-methoxyphenyl]-2-pyrrolidinone | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0054 | - |
adenosine 3',5'-cyclic phosphate | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine 3',5'-cyclic phosphate + H2O | Rattus norvegicus | PDE4B4 isoform may have a distinct functional role in regulating cAMP levels in specific cell types | adenosine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P14646 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | treatment of COS7 cells with forskolin, to elevate cAMP levels, produced activation of PDE4B4, which is associated with the phosphorylation of PDE4B4 on Ser-56 within UCR1 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
skeletal muscle | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine 3',5'-cyclic phosphate + H2O | - |
Rattus norvegicus | adenosine 5'-phosphate | - |
? | |
adenosine 3',5'-cyclic phosphate + H2O | PDE4B4 isoform may have a distinct functional role in regulating cAMP levels in specific cell types | Rattus norvegicus | adenosine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE4B4 | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000083 | - |
- |
Rattus norvegicus | rolipram |