Application | Comment | Organism |
---|---|---|
medicine | enzyme knock-down by RNAi reveals that it may be complemented by isoform PDEB1, but simultaneous ablation of PDEB1 and PDEB2 leads to cell death in bloodstream form trypanosomes. In vivo application of RNAi completely prevents infection and eliminates ongoing infections | Trypanosoma brucei |
medicine | enzyme knock-down by RNAi reveals that it may be complemented by isoform PDEB2, but simultaneous ablation of PDEB1 and PDEB2 leads to cell death in bloodstream form trypanosomes. In vivo application of RNAi completely prevents infection and eliminates ongoing infections | Trypanosoma brucei |
medicine | TbrPDEB1 and TbrPDEB2 are essential for virulence, making them valuable potential targets for new PDE-inhibitor based trypanocidal drugs | Trypanosoma brucei |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme knock-down by RNAi reveals that it may be complemented by isoform PDEB1, but simultaneous ablation of PDEB1 and PDEB2 leads to cell death in bloodstream form trypanosomes. In vivo application of RNAi completely prevents infection and eliminates ongoing infections | Trypanosoma brucei |
additional information | enzyme knock-down by RNAi reveals that it may be complemented by isoform PDEB2, but simultaneous ablation of PDEB1 and PDEB2 leads to cell death in bloodstream form trypanosomes. In vivo application of RNAi completely prevents infection and eliminates ongoing infections | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Trypanosoma brucei | 5737 | - |
cytoplasm | TbrPDEB2 is distributed between flagellum and cytoplasm | Trypanosoma brucei | 5737 | - |
flagellum | - |
Trypanosoma brucei | - |
- |
flagellum | TbrPDEB2 is distributed between flagellum and cytoplasm | Trypanosoma brucei | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Trypanosoma brucei | TbrPDEB1 and TbrPDEB2 are essential for virulence, making them valuable potential targets for new PDE-inhibitor based trypanocidal drugs | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Trypanosoma brucei | Q38F42 | isoform PDEB2 | - |
Trypanosoma brucei | Q38F46 | isoform PDEB2 | - |
Trypanosoma brucei | Q8WQX9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bloodstream form | - |
Trypanosoma brucei | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | TbrPDEB1 and TbrPDEB2 are essential for virulence, making them valuable potential targets for new PDE-inhibitor based trypanocidal drugs | Trypanosoma brucei | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDEB1 | - |
Trypanosoma brucei |
TbrPDEB1 | - |
Trypanosoma brucei |
TbrPDEB2 | - |
Trypanosoma brucei |