Activating Compound | Comment | Organism | Structure |
---|---|---|---|
amyloid beta peptide | residues 1-42, i.e. Abeta1-42, a formyl-peptid-receptor-like 1 agonist, activates 3-4fold in microglia and astrocytes, respectively, at 0.001 mM. Endocytosis of Abeta1-42 in glial cells is PLD-dependent | Rattus norvegicus | |
formylmethionyl-leucyl-proline | i.e. fMLF, activates 4fold in microglia and astrocytes, respectively, at 0.001 mM, the activation is inhibited by WRW4, a formyl-peptid-receptor-like 1 antagonist | Rattus norvegicus | |
additional information | no inhibition of PLD by WRW4 | Rattus norvegicus | |
phorbol 12-myristate 13-acetate | activates 13fold at 0.001 mM in microglia and astrocytes | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | PLD catalyzes the hydrolysis of phospholipids resulting in the generation of phosphatidic acid and the release of the polar head group. The enzyme also catalyzes a transphosphatidylation reaction, in which the aliphatic chain of the primary alcohol is transferred to the phosphatidyl moiety of the phosphatidic acid product | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | primary | Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
glial cell | - |
Rattus norvegicus | - |
microglia | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantification of transphosphatidylation activity of PLD in glial cells, overview | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PLD catalyzes the hydrolysis of phospholipids resulting in the generation of phosphatidic acid and the release of the polar head group. The enzyme also catalyzes a transphosphatidylation reaction, in which the aliphatic chain of the primary alcohol is transferred to the phosphatidyl moiety of the phosphatidic acid product | Rattus norvegicus | ? | - |
? | |
additional information | PLD also performs transphosphatidylation using ethanol as phosphatidyl acceptor | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLD | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | PLD mediates amyloid beta peptides endocytosis into glial cells, and ERK1/2 phosphorylation by a formyl-peptid-receptor-like 1, FPRL1, agonists in glial cells | Rattus norvegicus |