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Literature summary for 3.1.4.11 extracted from
- Expression pattern and sub-cellular distribution of phosphoinositide specific phospholipase C enzymes after treatment with U-73122 in rat astrocytoma cells (2010), J. Cell. Biochem., 110, 1005-1012.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| U73122 | - |
Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| additional information | isozyme distribution, overview | Rattus norvegicus | - |
- |
| nucleus | - |
Rattus norvegicus | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Rattus norvegicus | - |
| astrocytoma cell | PI-PLC expression pattern, overview | Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
| C6 glioma cell | - |
Rattus norvegicus | - |
| glia | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphoinositide specific phospholipase C | - |
Rattus norvegicus |
| PI-PLC | - |
Rattus norvegicus |
| PI-PLC beta1 | - |
Rattus norvegicus |
| PI-PLC beta3 | - |
Rattus norvegicus |
| PI-PLC beta4 | - |
Rattus norvegicus |
| PI-PLC gamma1 | - |
Rattus norvegicus |
| PI-PLC gamma2 | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | isoforms of PI-PLC family display different expression and/or sub cellular distribution under non-physiological conditions such as the rat astrocytes activation during neurodegeneration, the tumoural progression of some neoplasms and the inflammatory cascade activation after lipopolysaccharide administration. PI-PLC beta3 and PI-PLC gamma2 isoforms, whose expression and sub cellular localization significantly differ after U73122 inhibitor treatment | Rattus norvegicus |
| physiological function | PI-PLC enzymes interfere with the metabolism of inositol phospholipids, molecules involved in signal transduction, a complex process depending on various components | Rattus norvegicus |
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