Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3beta,27-dihydroxyurs-12-en-28-oic acid | - |
Homo sapiens | |
3beta,27-dihydroxyurs-12-en-28-oic acid | - |
Mus musculus | |
3beta,7'-diacetoxy-27- 4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
3beta,7'-diacetoxy-27- 4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | - |
Homo sapiens | |
3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | - |
Mus musculus | |
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | - |
Homo sapiens | |
3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | - |
Mus musculus | |
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | - |
Homo sapiens | |
3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | - |
Mus musculus | |
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester | - |
Homo sapiens | |
3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester | - |
Mus musculus | |
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | - |
Homo sapiens | |
3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | - |
Mus musculus | |
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester | - |
Homo sapiens | |
3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester | - |
Mus musculus | |
4-(E)-coumaric acid | - |
Homo sapiens | |
4-(E)-coumaric acid | - |
Mus musculus | |
adriamycin | - |
Homo sapiens | |
adriamycin | - |
Mus musculus | |
amentoflavone | - |
Homo sapiens | |
amentoflavone | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
CCD-18Co cell | - |
Homo sapiens | - |
HT-1197 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
P-388 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mus musculus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol specific phospholipase C | - |
Mus musculus |
phosphatidylinositol specific phospholipase C | - |
Homo sapiens |
phospholipase Cgamma1 | - |
Mus musculus |
phospholipase Cgamma1 | - |
Homo sapiens |
PI-PLC | - |
Mus musculus |
PI-PLC | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 value is less than 0.1 microM for adriamycin in in P388 cells, pH 7.0, 37°C | Mus musculus | additional information | |
additional information | - |
IC50 value is less than 0.1 microM for adriamycin in MCF7 cells, pH 7.0, 37°C | Homo sapiens | additional information | |
additional information | - |
the IC50 values for 3beta,7'-diacetoxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid, 3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester, 3beta,27-dihydroxyurs-12-en-28-oic acid, 3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid, and 4-(E)-coumaric acidare above 0.250 mM, pH 7.0, 37°C | Homo sapiens | additional information | |
0.0001 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | adriamycin | |
0.0004 | - |
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C | Homo sapiens | adriamycin | |
0.0007 | - |
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the A549 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C | Homo sapiens | adriamycin | |
0.0008 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
0.0008 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
0.0009 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.0009 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
0.001 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
0.0013 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | adriamycin | |
0.0013 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | adriamycin | |
0.0014 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
0.0017 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
0.0018 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
0.0019 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
0.002 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
0.0021 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
0.0021 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
0.0021 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
0.0021 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
0.0021 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
0.0021 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
0.0021 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
0.0021 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
0.0024 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.0027 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
0.0028 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
0.0029 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
0.0029 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
0.003 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
0.0032 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
0.0035 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
0.0037 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
0.0038 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.0038 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
0.0038 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
0.004 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
0.0041 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
0.0043 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
0.0043 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
0.0043 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
0.0045 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.0045 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.0047 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
0.0051 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.0054 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
0.0065 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
0.0066 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
0.0067 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
0.0072 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
0.0076 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
0.0091 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
0.0091 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
0.0095 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.01 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
0.0101 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | adriamycin | |
0.0143 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
0.0174 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
0.0175 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
0.0182 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
0.0186 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
0.022 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
0.0226 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.0229 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
0.0229 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
0.0245 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
0.0245 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
0.0246 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | adriamycin | |
0.0246 | - |
in HT-1 197 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | adriamycin | |
0.0246 | - |
sulforhodamine B, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C | Homo sapiens | adriamycin | |
0.0277 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
0.029 | - |
pH 7.0, 37°C | Homo sapiens | amentoflavone | |
0.0355 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
0.0357 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
0.0438 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
0.0441 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
0.0446 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
0.0503 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
0.0524 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
0.059 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
0.0614 | - |
sulforhodamine B, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.065 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.0666 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
0.0733 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
0.0737 | - |
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
0.0836 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid | |
0.1213 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester |