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Literature summary for 3.1.4.11 extracted from
- Phospholipase C{gamma}2 is critical for dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells (2009), J. Biol. Chem., 284, 7038-7046.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the activation of PLCgamma2 is dependent on Syk and Src family kinases | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | plc2-/- mice, in the absence of PLCgamma2, the activation of ERK and JNK MAPKs and the induction of transcription factors AP-1, NFAT, and NF-kB as well as the secretion of cytokines are severely compromised in dendritic cells | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| U-73122 | - |
Mus musculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| dendrite | - |
Mus musculus | 30425 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6 | - |
| Mus musculus C57BL/6 | - |
C57BL/6 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phospholipase Cgamma2 | - |
Mus musculus |
| PLCgamma1 | - |
Mus musculus |
| PLCgamma2 | - |
Mus musculus |
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