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Literature summary for 3.1.4.11 extracted from

  • Chen, Y.; Wang, X.; Di, L.; Fu, G.; Chen, Y.; Bai, L.; Liu, J.; Feng, X.; McDonald, J.M.; Michalek, S.; He, Y.; Yu, M.; Fu, Y.X.; Wen, R.; Wu, H.; Wang, D.
    Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis (2008), J. Biol. Chem., 283, 29593-29601.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information PLCgamma2-/- mice. PLCgamma2-deficient mice display impaired lymph node organogenesis but normal splenic structure and Peyer's patches Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus PLCgamma2 is essential for RANK (Receptor activator of NF-kB) signaling, and its deficiency leads to defective lymph node organogenesis and osteoclast differentiation ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8CIH5 PLCgamma2-deficient mice
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PLCgamma2 is essential for RANK (Receptor activator of NF-kB) signaling, and its deficiency leads to defective lymph node organogenesis and osteoclast differentiation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
phospholipase Cgamma2
-
 Mus musculus
PLCgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis Mus musculus