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Literature summary for 3.1.4.11 extracted from

  • Faenza, I.; Bregoli, L.; Ramazzotti, G.; Gaboardi, G.; Follo, M.Y.; Mongiorgi, S.; Billi, A.M.; Manzoli, L.; Martelli, A.M.; Cocco, L.
    Nuclear phospholipase C beta1 and cellular differentiation (2008), Front. Biosci., 13, 2452-2463.
    View publication on PubMed
Search for more literature for 3.1.4.11

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm in C2C12 cells PI-PLC beta3 is both in the nucleus and in the cytoplasm Homo sapiens 5737
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nucleus
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 Homo sapiens 5634
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nucleus in C2C12 cells PI-PLC beta1 is mainly located at the nucleus. During insulin-induced myoblast differentiation, PI-PLC beta1 is greatly increased at the nuclear level. The nuclear localization of PI-PLC beta1 is essential for induction of differentiation Mus musculus 5634
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nucleus in C2C12 cells PI-PLC beta3 is both in the nucleus and in the cytoplasm. During insulin-induced myoblast differentiation, expression of PI-PLC beta3 in C2C12 cells remains unchanged Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens
-
 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens PI-PLC beta1 could have a role in muscle hypertrophy taking place in human muscular dystrophy 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Mus musculus PI-PLC beta1 is essential in the IGF-1 mitogenic signaling pathway 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q01970
-
-
Homo sapiens Q9NQ66
-
-
Mus musculus Q9Z1B3
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-

Source Tissue

Source Tissue Comment Organism Textmining
B-16 cell
-
 Mus musculus
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C2C12 cell
-
 Mus musculus
-
erythroleukemia cell
-
 Mus musculus
-
HL-60 cell
-
 Homo sapiens
-
NIH-3T3 cell
-
 Mus musculus
-
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PI-PLC beta1 could have a role in muscle hypertrophy taking place in human muscular dystrophy Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PI-PLC beta1 is essential in the IGF-1 mitogenic signaling pathway Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

Synonyms

Synonyms Comment Organism
phospholipase C beta1
-
 Homo sapiens
phospholipase C beta1
-
 Mus musculus
phospholipase C beta3
-
 Homo sapiens
PI-PLC
-
 Homo sapiens
PI-PLC
-
 Mus musculus
PI-specific phospholipase C
-
 Homo sapiens
PI-specific phospholipase C
-
 Mus musculus