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Literature summary for 3.1.4.11 extracted from

  • Dwivedi, Y.; Mondal, A.C.; Rizavi, H.S.; Shukla, P.K.; Pandey, G.N.
    Single and repeated stress-induced modulation of phospholipase C catalytic activity and expression: role in LH behavior (2005), Neuropsychopharmacology, 30, 473-483.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus reduction in phospholipase C may be critical in the pathophysiology of depression and other stress-related disorders ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
brain cortex frontal cortex, single inescapable shock reduces PI-PLC activity in the frontal cortex and hippocampus of learned helplessness rats. Repeated inescapable shock not only reduced PI-PLC activity but also selectively decreases the expression of PLCbeta1 and PLCgamma1 isozymes Rattus norvegicus
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hippocampus single inescapable shock reduces PI-PLC activity in the frontal cortex and hippocampus of learned helplessness rats. Repeated inescapable shock not only reduced PI-PLC activity but also selectively decreases the expression of PLCbeta1 and PLCgamma1 isozymes Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
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 Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
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 ?
additional information reduction in phospholipase C may be critical in the pathophysiology of depression and other stress-related disorders Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
PI-PLC
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 Rattus norvegicus
PLCbeta1
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 Rattus norvegicus
PLCgamma1
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 Rattus norvegicus