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Literature summary for 3.1.4.11 extracted from
- Aggregated beta amyloid peptide 1-40 decreases Ca2+- and cholinergic receptor-mediated phosphoinositide degradation by alteration of membrane and cytosolic phospholipase C in brain cortex (2000), Neurochem. Res., 25, 189-196.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| soluble amyloid beta protein fragment 25-35 | activates PI-PLC | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aggregated amyloid beta protein | full-length Abeta 1-40, aggregated form inhibits Ca2+-regulated phosphoinositide degradation by cytosolic and membrane-bound PLC by 30-40%, inhibitor may interact with the Ca2+-binding site of enzyme, no inhibition by nonaggregated soluble full-length amyloid beta protein | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| plasma membrane | synaptic, bound to | Rattus norvegicus | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | maximal activation of PI-PLC by 2 mM CaCl2, Ca2+-dependent phosphoinositide degradation | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Rattus norvegicus | key enzyme in signal transduction generating the intracellular second messengers DAG and IP3 | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | second messengers | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar rats, adult | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebral cortex | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | phosphoinositide-specific | Rattus norvegicus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | key enzyme in signal transduction generating the intracellular second messengers DAG and IP3 | Rattus norvegicus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | second messengers | ? | |
| arachidonoylphosphatidylinositol + H2O | - |
Rattus norvegicus | myo-inositol 1-phosphate + 1,2-diarachidonoylglycerol | - |
? | |
| phosphatidylinositol + H2O | - |
Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | - |
assay at, phosphatidylinositol 4,5-bisphosphate as substrate | Rattus norvegicus |
| 7.8 | - |
assay at, phosphatidylinositol as substrate | Rattus norvegicus |
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