Any feedback?
Literature summary for 3.1.4.11 extracted from
- Studies on the properties of a soluble phosphatidylinositol-phosphodiesterase of rabbit iris smooth muscle (1980), Biochim. Biophys. Acta, 614, 425-434.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | at 0.05-5 mM, inhibition is completely reversed by Ca2+ | Oryctolagus cuniculus |  |
| EDTA | at 0.05-5 mM, inhibition is completely reversed by Ca2+ | Oryctolagus cuniculus | |
| EGTA | at 0.05-5 mM, inhibition is completely reversed by Ca2+ | Oryctolagus cuniculus | |
| La3+ | at 0.05-5 mM, inhibition is completely reversed by Ca2+ | Oryctolagus cuniculus | |
| Mg2+ | at 0.05-5 mM, inhibition is completely reversed by Ca2+ | Oryctolagus cuniculus | |
| Mn2+ | at 0.05-5 mM, inhibition is completely reversed by Ca2+ | Oryctolagus cuniculus | |
| Sr2+ | at higher concentrations (greater than 0.25 mM) markedly inhibited, inhibition is completely reversed by Ca2+ | Oryctolagus cuniculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | enzyme has an absolute requirement for Ca2+ | Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Oryctolagus cuniculus | enzyme is specific for phosphoinositides | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | enzyme is not exclusively cytosolic | Oryctolagus cuniculus | - |
| smooth muscle | iris | Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diarachidonoylphosphatidylinositol + H2O | - |
Oryctolagus cuniculus | 1,2-diacylglycerol + 1D-myo-inositol 1-phosphate | a mixture of 86% myoinositol 1-phosphate and 14% myoinositol 1,2-cyclic phosphate | ? | |
| additional information | enzyme is specific for phosphoinositides | Oryctolagus cuniculus | ? | - |
? | |
| additional information | enzyme is not active with phosphatidylcholine and phosphatidylethanolamine as substrate | Oryctolagus cuniculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| monophosphatidylinositol inositolphosphohydrolase | - |
Oryctolagus cuniculus |
| phosphatidylinositol phosphodiesterase | - |
Oryctolagus cuniculus |
| phosphatidylinositol-phosphodiesterase | - |
Oryctolagus cuniculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.6 | - |
- |
Oryctolagus cuniculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 7 | pH 4.5: about 50% of maximal activity, pH 7.0: about 40% of maximal activity | Oryctolagus cuniculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
