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Literature summary for 3.1.4.11 extracted from

  • Low, M.G.; Weglicki, W.B.
    Resolution of myocardial phospholipase C into several forms with distinct properties (1983), Biochem. J., 215, 325-334.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.11

Activating Compound

Activating Compound Comment Organism Structure
deoxycholate stimulates activity of enzyme I, II and III at pH 7 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
EGTA
-
 Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ enzyme requires 2-5 mM CaCI2 for maximal activity Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000 43000 enzyme form II, gel filtration Bos taurus
58000 76000 enzyme form III, gel filtration Bos taurus
105000 120000 enzyme form I, gel filtration Bos taurus
256000 271000 enzyme form IV, gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine are no substrates Bos taurus ?
-
 ?
phosphatidylinositol + H2O
-
 Bos taurus ?
-
 ?
phosphatidylinositol 4,5-bisphosphate + H2O
-
 Bos taurus ?
-
 ?
phosphatidylinositol 4-phosphate + H2O
-
 Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
myocardial phospholipase C type I, II, III, and IV Bos taurus
phospholipase C type I, II, III, and IV Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5 5.5 type I, II, and III. The major form (III) also has substantial activity at pH 7.0 and above 4 Bos taurus