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Literature summary for 3.1.4.11 extracted from
- Triphosphoinositide phosphodiesterase in a protozoan - Crithidia fasciculata (1973), Biochim. Biophys. Acta, 326, 194-200.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cetyltrimethylammonium bromide | stimulates | Crithidia fasciculata |  |
| diethyl ether | stimulates | Crithidia fasciculata | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| anionic amphipathic substances | - |
Crithidia fasciculata | |
| Cys | - |
Crithidia fasciculata | |
| EDTA | complete inhibition at 1 mM | Crithidia fasciculata | |
| EGTA | - |
Crithidia fasciculata | |
| Hg2+ | - |
Crithidia fasciculata | |
| iodoacetamide | 1.0 mM, 16% inhibition | Crithidia fasciculata | |
| Phenylmercuriacetate | - |
Crithidia fasciculata | |
| reduced glutathione | - |
Crithidia fasciculata | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Crithidia fasciculata | |
| K+ | stimulates | Crithidia fasciculata | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Crithidia fasciculata | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylinositol 4,5-bisphosphate + H2O | - |
Crithidia fasciculata | D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.2 | - |
Crithidia fasciculata |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.4 | 7.8 | pH 6.4: about 55% of maximal activity, pH 7.8: about 20% of maximal activity | Crithidia fasciculata |
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