Cloned (Comment) | Organism |
---|---|
SaeRS is required for expression of the nuc gene, expression from plasmid containing the nuc promoter coupled to sGFP (pCM20), transformed into the Staphylococcus aureus USA300 wild-type-LAC and sae, agr, and sigB mutant strains | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
several strains and isolates | - |
Synonyms | Comment | Organism |
---|---|---|
staphylococcus aureus nuclease | - |
Staphylococcus aureus |
Organism | Comment | Expression |
---|---|---|
Staphylococcus aureus | SaeRS is required for expression of the nuc gene | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | the nuc gene necoding Staphylococcus aureus nuclease is under the control of the SaeRS two-component system, which is a major regulator of Staphylococcus aureus virulence determinants, the enzyme is an SaeRS-dependent virulence factor. With community-associated methicillin-resistant Staphylococcus aureus in a mouse model of peritonitis, in vivo expression of Nuc activity in an SaeRS-dependent manner is observed and determination of Nuc as a virulence factor that is important for in vivo survival, confirming the enzyme's role as a contributor to invasive disease. The enzyme contributes to pathogen survival during invasive disease | Staphylococcus aureus |