Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Staphylococcus aureus | |
Mg2+ | required | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
a community-acquired CA-MRSA strain, gene nuc | - |
Staphylococcus aureus USA 300 LAC | - |
a community-acquired CA-MRSA strain, gene nuc | - |
Synonyms | Comment | Organism |
---|---|---|
staphylococcus aureus nuclease | - |
Staphylococcus aureus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Staphylococcus aureus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Staphylococcus aureus |
General Information | Comment | Organism |
---|---|---|
physiological function | Staphylococcus aureus nuclease mediates resistance against entrapment and killing within neutrophil extracellular traps, which consist of a nuclear DNA backbone associated with antimicrobial peptides, histones and proteases that provide a matrix to entrap and kill various microbes. Promoting role of Staphylococcus aureus nuclease in neutrophil extracellular traps degradation and virulence in a murine respiratory tract infection model, overview. Staphylococcus aureus nuclease facilitates evasion from neutrophil extracellular trap entrapment, and mediates resistance against extracellular killing by neutrophils | Staphylococcus aureus |