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Literature summary for 3.1.31.1 extracted from

  • Kuruma, H.; Kamata, Y.; Takahashi, H.; Igarashi, K.; Kimura, T.; Miki, K.; Miki, J.; Sasaki, H.; Hayashi, N.; Egawa, S.
    Staphylococcal nuclease domain-containing protein 1 as a potential tissue marker for prostate cancer (2009), Am. J. Pathol., 174, 2044-2050.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.31.1

Application

Application Comment Organism
medicine as staphylococcal nuclease domain-containing protein 1 mRNA is overexpressed in cancer cells, the growth of these cells is suppressed following staphylococcal nuclease domain-containing protein 1 knock-down in vitro, thus representing a promising prostate cancer biomarker and therapeutic target, evidence for the diagnostic potential of staphylococcal nuclease domain-containing protein 1 in prostate surgical specimens equivalent or better than that of alpha-methylacyl-CoA racemase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7KZF4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Epstein-Barr virusencoded transcription factor 2 co-activator p100
-
 Homo sapiens
SND1
-
 Homo sapiens
staphylococcal nuclease
-
 Homo sapiens
staphylococcal nuclease domain-containing protein 1
-
 Homo sapiens
tudor staphylococcal nuclease
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in hyperplasia specimens and normal epithelium, protein is weakly or negatively expressed down
Homo sapiens knocked down staphylococcal nuclease domain-containing protein 1 in vitro with small interfering RNA causes a significant decrease in cell growth additional information
Homo sapiens staphylococcal nuclease domain-containing protein 1 is highly expressed in recurrent androgen-insensitive prostate cancer tissues, protein expression intensity increases with increasing grade and aggressiveness of the cancer, staphylococcal nuclease domain-containing protein 1 mRNA is highly expressed in the cytoplasm of cancer cells but is negative to weak in noncancerous cells up

General Information

General Information Comment Organism
physiological function staphylococcal nuclease domain-containing protein 1 is a component of the RNA-induced splicing complex that mediates RNA interference, leading to degradation of specific mRNAs Homo sapiens