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Literature summary for 3.1.31.1 extracted from

  • Hossain, M.J.; Korde, R.; Singh, S.; Mohmmed, A.; Dasaradhi, P.V.; Chauhan, V.S.; Malhotra, P.
    Tudor domain proteins in protozoan parasites and characterization of Plasmodium falciparum tudor staphylococcal nuclease (2008), Int. J. Parasitol., 38, 513-526.
    View publication on PubMed

Application

Application Comment Organism
drug development attractive potential target for the development of anti-malarial drugs Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment) Organism
expression of protein fragment results in the formation of insoluble inclusion bodies, successful expression as fusion protein with Maltose Binding Protein Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
3',5'-deoxythymidine diphosphate addition to the cell culture medium blocks further growth Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm during trophozoite and schizont stages parts of enzyme localized in the cytoplasm Plasmodium falciparum 5737
-
nucleus mainly nuclear localization Plasmodium falciparum 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
95000
-
x * 95000, SDS-PAGE of the recombinant fusion protein with Maltose Binding Protein Plasmodium falciparum
110000
-
x * 110000, SDS-PAGE, native protein Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Plasmodium falciparum essential enzyme in the life cycle of Plasmodium falciparum ?
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
strains 3D7 and W2mef, enzyme expressed in all three blood stages: ring, trophozoite and schizont stage
-

Purification (Commentary)

Purification (Comment) Organism
recombinant fusion protein with Maltose Binding Protein Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GFP-ssDNA + H2O
-
Plasmodium falciparum ? partial degradation ?
GFP-ssRNA + H2O
-
Plasmodium falciparum ? complete degradation ?
M13mp18 DNA + H2O circular single stranded DNA Plasmodium falciparum ?
-
?
additional information essential enzyme in the life cycle of Plasmodium falciparum Plasmodium falciparum ?
-
?
additional information GFP-dsDNA and GFP-dsRNA are not used as substrates Plasmodium falciparum ?
-
?

Subunits

Subunits Comment Organism
? x * 110000, SDS-PAGE, native protein Plasmodium falciparum
? x * 95000, SDS-PAGE of the recombinant fusion protein with Maltose Binding Protein Plasmodium falciparum

Synonyms

Synonyms Comment Organism
PfTSN
-
Plasmodium falciparum
Staphylococcus aureus nuclease homologue
-
Plasmodium falciparum
TSN
-
Plasmodium falciparum
tudor staphylococcal nuclease
-
Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.05
-
after 48 h Plasmodium falciparum 3',5'-deoxythymidine diphosphate