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Literature summary for 3.1.31.1 extracted from

  • Schwehm, J.M.; Fitch, C.A.; Dang, B.N.; Garcia-Moreno, E.B.; Stites, W.E.
    Changes in stability upon charge reversal and neutralization substitution in staphylococcal nuclease are dominated by favorable electrostatic effects (2003), Biochemistry, 42, 1118-1128.
    View publication on PubMed
Search for more literature for 3.1.31.1

Protein Variants

Protein Variants Comment Organism
D143K charge reversal Staphylococcus sp.
D143N charge reversal Staphylococcus sp.
D19K charge reversal Staphylococcus sp.
D19L charge reversal Staphylococcus sp.
D21K charge reversal Staphylococcus sp.
D21N charge reversal Staphylococcus sp.
D77K charge reversal Staphylococcus sp.
D77N charge reversal Staphylococcus sp.
E10K charge reversal Staphylococcus sp.
E10Q charge reversal Staphylococcus sp.
E122K charge reversal Staphylococcus sp.
E122Q charge reversal Staphylococcus sp.
E135K charge reversal Staphylococcus sp.
E135Q charge neutralization Staphylococcus sp.
E57K charge reversal Staphylococcus sp.
E57Q charge reversal Staphylococcus sp.
E67Q charge reversal Staphylococcus sp.
E73K charge reversal Staphylococcus sp.
E73Q charge reversal Staphylococcus sp.
E75K charge reversal Staphylococcus sp.
E75Q charge reversal Staphylococcus sp.
H124E charge reversal Staphylococcus sp.
H124Q charge neutralization Staphylococcus sp.
K127E charge reversal Staphylococcus sp.
K127Q charge neutralization Staphylococcus sp.
K133Q charge neutralization Staphylococcus sp.
K28E charge reversal Staphylococcus sp.
K28Q charge neutralization Staphylococcus sp.
K48E charge reversal Staphylococcus sp.
K48Q charge neutralization Staphylococcus sp.
K63E charge reversal Staphylococcus sp.
K63Q charge neutralization Staphylococcus sp.
K64E charge reversal Staphylococcus sp.
K64Q charge neutralization Staphylococcus sp.
K70E charge reversal Staphylococcus sp.
K70Q charge neutralization Staphylococcus sp.
K78E charge reversal Staphylococcus sp.
K78Q charge neutralization Staphylococcus sp.
K84E charge reversal Staphylococcus sp.
K84Q charge neutralization Staphylococcus sp.
K97E charge reversal Staphylococcus sp.
K97Q charge neutralization Staphylococcus sp.
additional information almost all mutations are destabilizing, the average loss of stability for all of the charge neutralization substitutions is 0.5 kcal/mol and the average loss of stability for all of the charge reversal substitutions is 1.0 kcal/mol Staphylococcus sp.

Organism

Organism UniProt Comment Textmining
Staphylococcus sp.
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