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Literature summary for 3.1.3.67 extracted from

  • Semba, S.; Satake, S.; Matsushita, M.; Yokozaki, H.
    Phosphatase activity of nuclear PTEN is required for CDX2-mediated intestinal differentiation of gastric carcinoma (2009), Cancer Lett., 274, 143-150.
    View publication on PubMed

Application

Application Comment Organism
diagnostics putative biomarker, nuclear localization of PTEN is important for intestinal differentiation of gastric carcinomas, the loss of cytoplasmatic PTEN expression is correlated with poor gastric carcinoma prognosis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
Wild type and mutant cDNA is subcloned in the vector pcDNA3.1 to generate expression vectors, transduction of recombinant PTEN and PTEN mutant into TMK-1 cells. Recombinant PTEN effectively downregulates phospho-Akt levels as well as the LY294002 phosphatidylinositol 3-kinase inhibitor Homo sapiens

Protein Variants

Protein Variants Comment Organism
G129E transduction of recombinant PTEN in to TMK-1 cells promotes nuclear localization with increased mRNA levels of CDX2 and intestinal claudins, whereas the G129 dead phosphatase mutant has no effect Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens nuclear PTEN is not the same as cytoplasmic PTEN, nuclear PTEN has diverse roles particularly in chromosome stability, DNA repair, cell cycle arrest and cellular stability ?
-
?
additional information Homo sapiens PTEN tumor suppressor negatively regulates the phosphatidylinositol 3-kinase-AKT pathway ?
-
?
phosphatidylinositol 3,4,5-trisphosphate + H2O Homo sapiens dephosphorylating phosphatidyl inositol 4,5-bisphosphate + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
ubiquitination mono-ubiquitination-mediated PTEN stabilization is essential for its tumor suppression activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
gastric cancer cell tissue from patients with sporadic gastric carcinoma Homo sapiens
-
TMK-1 cell gastric cancer cell, PTEN negative and phospho-Akt-positive Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information nuclear PTEN is not the same as cytoplasmic PTEN, nuclear PTEN has diverse roles particularly in chromosome stability, DNA repair, cell cycle arrest and cellular stability Homo sapiens ?
-
?
additional information PTEN tumor suppressor negatively regulates the phosphatidylinositol 3-kinase-AKT pathway Homo sapiens ?
-
?
phosphatidylinositol 3,4,5-trisphosphate + H2O dephosphorylating Homo sapiens phosphatidyl inositol 4,5-bisphosphate + phosphate
-
?

Synonyms

Synonyms Comment Organism
PTEN
-
Homo sapiens