Application | Comment | Organism |
---|---|---|
diagnostics | putative biomarker, nuclear localization of PTEN is important for intestinal differentiation of gastric carcinomas, the loss of cytoplasmatic PTEN expression is correlated with poor gastric carcinoma prognosis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
Wild type and mutant cDNA is subcloned in the vector pcDNA3.1 to generate expression vectors, transduction of recombinant PTEN and PTEN mutant into TMK-1 cells. Recombinant PTEN effectively downregulates phospho-Akt levels as well as the LY294002 phosphatidylinositol 3-kinase inhibitor | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G129E | transduction of recombinant PTEN in to TMK-1 cells promotes nuclear localization with increased mRNA levels of CDX2 and intestinal claudins, whereas the G129 dead phosphatase mutant has no effect | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | nuclear PTEN is not the same as cytoplasmic PTEN, nuclear PTEN has diverse roles particularly in chromosome stability, DNA repair, cell cycle arrest and cellular stability | ? | - |
? | |
additional information | Homo sapiens | PTEN tumor suppressor negatively regulates the phosphatidylinositol 3-kinase-AKT pathway | ? | - |
? | |
phosphatidylinositol 3,4,5-trisphosphate + H2O | Homo sapiens | dephosphorylating | phosphatidyl inositol 4,5-bisphosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
ubiquitination | mono-ubiquitination-mediated PTEN stabilization is essential for its tumor suppression activity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric cancer cell | tissue from patients with sporadic gastric carcinoma | Homo sapiens | - |
TMK-1 cell | gastric cancer cell, PTEN negative and phospho-Akt-positive | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | nuclear PTEN is not the same as cytoplasmic PTEN, nuclear PTEN has diverse roles particularly in chromosome stability, DNA repair, cell cycle arrest and cellular stability | Homo sapiens | ? | - |
? | |
additional information | PTEN tumor suppressor negatively regulates the phosphatidylinositol 3-kinase-AKT pathway | Homo sapiens | ? | - |
? | |
phosphatidylinositol 3,4,5-trisphosphate + H2O | dephosphorylating | Homo sapiens | phosphatidyl inositol 4,5-bisphosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PTEN | - |
Homo sapiens |