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Literature summary for 3.1.3.5 extracted from

  • Tsushima, K.
    Properties of cytosol 5-nucleotidase and its role in purine nucleotide metabolism (1986), Adv. Enzyme Regul., 25, 181-200.
    View publication on PubMed

General Stability

General Stability Organism
ATP protects against trypsin digestion Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
phosphate
-
Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.31
-
5'-IMP
-
Gallus gallus
0.53
-
5'-GMP
-
Gallus gallus
1.4
-
5'-dGMP
-
Gallus gallus
18
-
5'-AMP
-
Gallus gallus
23
-
5'-UMP
-
Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Gallus gallus 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ activation Gallus gallus
Mg2+ activation Gallus gallus
Mn2+ slight activation Gallus gallus
Ni2+ slight activation Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000
-
4 * 51000, SDS-PAGE Gallus gallus
180000
-
gel filtration Gallus gallus
205000
-
sucrose density gradient centrifugation Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
Gallus gallus adenosine + phosphate
-
?
5'-CMP + H2O
-
Gallus gallus cytidine + phosphate
-
?
5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Gallus gallus deoxyguanosine + phosphate
-
?
5'-GMP + H2O
-
Gallus gallus guanosine + phosphate
-
?
5'-IMP + H2O
-
Gallus gallus inosine + phosphate
-
?
5'-UMP + H2O
-
Gallus gallus uridine + phosphate
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 51000, SDS-PAGE Gallus gallus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
ATP protects against inactivation Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Gallus gallus