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Literature summary for 3.1.3.5 extracted from

  • Hasegawa, T.; Bouis, D.; Liao, H.; Visovatti, S.H.; Pinsky, D.J.
    Ecto-5' nucleotidase (CD73)-mediated adenosine generation and signaling in murine cardiac allograft vasculopathy (2008), Circ. Res., 103, 1410-1421.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine phosphohydrolysis of AMP by CD73 on graft-resident or circulating cells diminishes transendothelial leukocyte trafficking and mitigates inflammatory and immune sequelae of cardiac transplantation via the A2B adenosine receptor, CD73 deficiency increases graft expression of cytokines, chemokines, and adhesion molecules, and aggravates cardiac allograft vasculopathy and graft tolerance Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Mus musculus
-
heart
-
 Mus musculus
-
T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Mus musculus adenosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CD73
-
 Mus musculus
ecto-5' nucleotidase
-
 Mus musculus