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Literature summary for 3.1.3.5 extracted from

  • Borowiec, A.; Lechward, K.; Tkacz-Stachowska, K.; Skladanowski, A.C.
    Adenosine as a metabolic regulator of tissue function: production of adenosine by cytoplasmic 5'-nucleotidases (2006), Acta Biochim. Pol., 53, 269-278.
    View publication on PubMed
Search for more literature for 3.1.3.5

Activating Compound

Activating Compound Comment Organism Structure
2,3-bisphosphoglycerate
-
 Homo sapiens
ADP
-
 Homo sapiens
ADP strongly activated by ADP Homo sapiens
ATP
-
 Homo sapiens
dATP
-
 Homo sapiens
diadenosine 5',5'''-P1,P4-tetraphosphate
-
 Homo sapiens
GTP
-
 Homo sapiens
GTP activates Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5'-deoxy-5'-S-isobutylthioadenosine
-
 Homo sapiens
5-ethynyldideoxyuridine selective inhibitor Homo sapiens
6-Thiopurine
-
 Homo sapiens
N-(4-(4-methoxyphenyl)thiazol-2-yl)acrylamide selective inhibitor Homo sapiens
pentoxifillin
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.46
-
 5'-AMP partially purified enzyme isolated from heart Homo sapiens
1.9
-
 5'-AMP recombinant enzyme from heart Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+
-
 Homo sapiens
Mg2+
-
 Homo sapiens
Mn2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
erythrocyte
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
lymphoid cell
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
testis
-
 Homo sapiens
-
uterus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Homo sapiens adenosine + phosphate
-
 ?
5'-CMP + H2O
-
 Homo sapiens cytidine + phosphate
-
 ?
5'-dCMP + H2O
-
 Homo sapiens deoxycytidine + phosphate
-
 ?
5'-dCMP + H2O
-
 Homo sapiens 2'-deoxycytidine + phosphate
-
 ?
5'-dGMP + H2O
-
 Homo sapiens deoxyguanosine + phosphate
-
 ?
5'-dIMP + H2O
-
 Homo sapiens deoxyinosine + phosphate
-
 ?
5'-dTMP + H2O
-
 Homo sapiens deoxythymidine + phosphate
-
 ?
5'-dUMP + H2O
-
 Homo sapiens deoxyuridine + phosphate
-
 ?
5'-GMP + H2O
-
 Homo sapiens guanosine + phosphate
-
 ?
5'-IMP + H2O
-
 Homo sapiens inosine + phosphate
-
 ?
5'-UMP + H2O
-
 Homo sapiens uridine + phosphate
-
 ?
5'-XMP + H2O
-
 Homo sapiens xanthosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
5'-NT
-
 Homo sapiens
AMP-selective 5'-nucleotidase
-
 Homo sapiens
cN-I has a high affinity for both nucleoside and deoxynucleoside monophosphates, the latter, however, are converted with a much lower rate Homo sapiens
cN-II
-
 Homo sapiens
cN-III
-
 Homo sapiens
cytoplasmic 5'-nucleotidase II (IMP-selective or GMP/IMP-selective)
-
 Homo sapiens
cytoplasmic 5'-nucleotidase III
-
 Homo sapiens
cytoplasmic 5'-nucleotidase-I (AMP-selective)
-
 Homo sapiens
e5'-NT
-
 Homo sapiens
ecto-5'-nucleotidase
-
 Homo sapiens
high-Km 5'-NT
-
 Homo sapiens
IMP/GMP selective 5'-NT
-
 Homo sapiens
P5'N-1
-
 Homo sapiens
PN-I
-
 Homo sapiens
purine 5'-NT
-
 Homo sapiens
UMPH-1
-
 Homo sapiens
uridine monophosphate hydrolase-1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.02
-
-
 Homo sapiens 5-ethynyldideoxyuridine