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Literature summary for 3.1.3.48 extracted from

  • Mitra, A.; Sasikumar, K.; Parthasaradhi, B.V.; Radha, V.
    The tyrosine phosphatase TC48 interacts with and inactivates the oncogenic fusion protein BCR-Abl but not cellular Abl (2013), Biochim. Biophys. Acta, 1832, 275-284.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in K-562 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D182A inactive Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by H2O2 treatment Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P17706
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information does not dephosphorylate c-Abl Homo sapiens ?
-
?
phosphorylated BCR-Abl + H2O
-
Homo sapiens BCR-Abl + phosphate
-
?

Synonyms

Synonyms Comment Organism
TC48 isoform Homo sapiens
TCPTP
-
Homo sapiens
tyrosine phosphatase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function isoform TC48 inhibits proliferation and enhances sensitivity of K562 cells to STI571 Homo sapiens